VIRGINIA COMMONWEALTH UNIVERSITY
Center for Rehabilitation Science and Engineering
Study Information
Title:
Body composition assessment in spinal cord injury
PI:
David Gater
Contact:
Description:
The purpose of this project is to evaluate and compare different body composition assessment techniques with 4-compartment modeling (considered the current gold standard) and to determine associations with secondary comorbidities in Spinal Cord Injury (SCI), in order to efficiently predict those persons at risk for metabolic syndrome. One hundred twenty 18-65 y.o. individuals with chronic (>1 year) motor complete C5-L2 will be undergo body composition assessment with 4-compartment modeling using hydrostatic weighing, DXA, and total body water assessment. An additional 50 subjects will be utilized for cross validation in Year 3. Additionally, MRI scans will be obtained for visceral fat assessment. MRI visceral fat, DXA, BIA, and anthropometric measures (skin folds, circumferences, diameters, and lengths) will be assessed and validated against the gold standard 4-compartment model. Biomarkers associated with the metabolic syndrome, including insulin sensitivity, blood pressure, inflammatory markers, and lipid profiles will also be assessed, and relationship with markers of adiposity will be determined .
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